Research ·
Anthropic Claude discovers novel ART enzyme system with CRISPR-like repeats
Anthropic published (Sept 23) early results from its Bay Area life-sciences lab: Claude agents autonomously discovered array-associated reverse transcriptases (ART)—a previously uncharacterized bacteriophage enzyme system with CRISPR-like DNA repeat arrays—after ~950 agents spent 21 hours and ~210 million tokens mining reverse-transcriptase families from a large DNA database with only a high-level prompt and later human lab validation. Claude spotted tandem repeats beside an odd RT, counted spacing, checked literature, and filed a candidate report; ART pairs an RT, an accessory protein, and an expressed short-RNA repeat array with traits Anthropic says have co-occurred mainly in programmable DNA-cutting/copying systems. Function remains unknown; a pre-print is public, and CRISPR pioneer Feng Zhang called the RT–RNA-repeat association “genuinely intriguing.” Distinct from the Reuters wet-lab confirmation card, LSVP, OpenEvidence medical AI, and Opus 5.5.
Source: Anthropic





